Hello everyone. Dr. DiMattina here. Frozen embryo transfer (FET) for stimulated IVF greatly improves one’s chances for a successful IVF Many studies show (and my experience agrees) that frozen embryo transfer (FET) for stimulated IVF greatly improves one’s chances for a successful IVF procedure compared to performing a fresh embryo transfer in the patients’ stimulation cycle. I have previously written about this but I think this topic deserves more attention as I have recently seen many patients who underwent stimulated IVF elsewhere with their embryo transferred fresh in their stimulation cycle but without any success. And, if preimplantation genetic screening (PGS) is performed the pregnancy rates are further increased. Dominion Fertility only transfers FET when we perform stimulated IVF At Dominion Fertility, we only transfer frozen-thawed embryos (FET) when we perform stimulated IVF regardless of the number of embryos produced or whether or not the patient undergoes PGS or not. We perform FET in either the patient’s’ natural cycle (NCFET) or in a medicated FET cycle using natural hormones to create a healthy endometrium for the embryo. The pregnancy rates using NCFET or medicated FET are the same. Why no fresh embryo transfer in a stimulated IVF cycle? Studies clearly show that the ovarian stimulation drugs often adversely affect the endometrium causing an unfavorable environment for embryo implantation. This effect can be readily circumvented by freezing the embryo and later transferring it in either a natural non-stimulated cycle or a medicated FET cycle. Either way greatly improves the odds for success. Our IVF implantation rates exceed 65% using FET and PGS For 2016, our IVF implantation rates exceed 65% for all patients undergoing stimulated IVF provided we transfer the embryo in a FET cycle and we use PGS. Thus, most patients are successful after only 1 or 2 embryo transfers. In those few patients who are unsuccessful after 2 failed FET’s we usually recommend testing the endometrium for receptivity problems using an endometrial receptivity assay. The take home message here is to use frozen embryo transfer to improve one’s implantation success and PGS to even further optimize the chances for pregnancy. It works for most of our patients. Best wishes to all! Michael DiMattina, M.D. Selected References: Shapiro BS et al, Clinical rationale for cryopreservation of entire embryo cohorts in lieu of fresh transfer. Fertil Steril 2014: 102:3-9 Gomaa H et al, Elective single embryo transfer. Is frozen better that fresh? JBRA Assist. Reprod.