What is Preimplantation Genetic Testing?
Embryos produced by In Vitro Fertilization (IVF) are grown for 5-6 days until they reach the blastocyst stage. In the blastocyst stage, the embryo is composed of two different kinds of cells:
- Inner cell mass (ICM): these cells make the baby
- Trophoblast: these cells support implantation and help make the placenta
For genetic testing, we perform an embryo biopsy to remove some of the trophoblast cells from the blastocysts. The blastocysts are frozen until the genetic analysis for each embryo is completed.
The trophoblast cells are then prepared by our embryologist and shipped to a specialty genetic testing lab. The lab will already have information about the parents and their families in order to better identify the abnormal gene. At the lab, the cells are either tested for PGT-A (formerly PGS), PGT-M (formerly PGD), or both.
Doctors at our center will review the genetics report and, in consultation with the patients, advise which embryos are normal and available for embryo transfer.
What's the Difference Between PGT-A and PGT-M?
Preimplantation genetic testing for aneuploidy (PGT-A) provides information about the embryo’s chromosomes to detect Trisomy, whereas preimplantation genetic testing for monogenetic/single-gene diseases (PGT-M) looks for the presence of a specific, disease-causing gene such Cystic Fibrosis or Sickle Cell.
PGT-A tests embryos for the presence and the correct number of every chromosome. Over 90% of our IVF patients utilize PGT-A as a part of their treatment plan.Learn more About PGT-A
PGT-M tests embryos for the presence of a specific abnormal gene.
Preimplantation Genetic Testing FAQ
Blogs & Resources
Signs of Infertility in Men
Did you know male factor infertility may affect 40% of couples with infertility? Learn about the signs of infertility in men, what causes it, and what to do if you’re experiencing infertility.
Am I Ovulating? Ovulation Tracking and Signs for Determining the Fertile Window
Couples who have sex at the right time increase their chances of achieving conception by 25%. Read on to learn how to know if you are ovulating and ways to determine the fertile window.
7 Ways to Prepare Your Body for Pregnancy
To increase your chances of pregnancy, you'll want to be as healthy as possible before trying to conceive. Here's a checklist to prepare for pregnancy.
Will CoQ10 Improve Fertility? Your Questions about Coenzyme Q10 Answered.
Fertility specialists are increasingly recommending supplement Coenzyme Q10 (CoQ10). Does it CoQ10 improve fertility? Read on for answers.
Your Finance Guide for Fertility Treatment
Here's your Finance Guide to Fertility Treatment to highlight typical costs, financing providers, working with insurance, and more.
PCOS: Signs and Symptoms
PCOS may cause infertility. What are PCOS signs and symptoms a woman should look for? Learn what PCOS is and how to treat it.
10 Misconceptions in Fertility & Fertility Care
Fertility myths and misconceptions can interfere with your efforts to conceive. Get correct information from your healthcare provider.
Understanding the In Vitro Fertilization Process
There are four basic steps to IVF — ovarian stimulation, egg collection, egg fertilization, and embryo transfer. Let's take a closer look.
Dominion Fertility Named Top Healthcare Professionals for 2022 in Modern Luxury DC Magazine
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Your reproductive health fluctuates as you get older. Learn more about egg health and sperm health across various ages to maximize your chances of pregnancy.
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Secondary infertility is the inability to get pregnant or carry a baby to full term after having previously conceived with ease.
What is Frozen Embryo Transfer, and is it Right for Me?
This article covers the differences between a frozen and fresh embryo transfer, the advantages of FET, and who are good candidates for FET.
Overcoming Pregnancy Loss
Pregnancy loss can feel overwhelming and isolating, but you are not alone. See our recommended resources for navigating pregnancy loss.
Does Insurance Cover Fertility Treatment?
Does insurance cover fertility treatment? At Dominion Fertility, we’re here to help make your path to parenthood as seamless as possible. Here are our helpful tips for finding out if your insurance covers fertility treatments.
Dominion Fertility: Real Success Stories
By taking a moment to share the stories of our patients, in their own words, we hope to make your decision feel less daunting. You are not alone in your path to pregnancy and parenthood.
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How to cope with infertility during the holiday season. Take a moment to care for your own mental health.Here are some strategies and resources you can use to show self-care this holiday season.
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Does a Woman's Fertility Vary With Age? Dominion Fertility answers what you need to consider to have a healthy pregnancy after 35.
Holistic Ways to Improve Your Fertility
At Dominion Fertility, we individualize patient care to best suit the needs of every person that walks into our offices. Our job is to best serve you.
Healthy lifestyle leads to higher pregnancy rates
Fertility conditions are improved with a healthy lifestyle. Read about Dominion Fertility's thoughts on increased pregnancy rates with healthier living.
How to Get Pregnant
How do you get pregnant? Dominion Fertility offers some tips on everyday practices to implement to improve fertility. Still having trouble? Contact us today!
Fact or Fiction? Investigating 7 Common Fertility & Pregnancy Myths
Can smoking cause infertility? Should I avoid BPA? How much caffeine can I have? Dominion Fertility answers 7 common fertility myths here!
New Year, New Habits: Ringing in 2020
A new year affords new opportunities to evaluate your goals and things you’re working towards. When making New Year’s Resolutions, most people decide to pursue better physical health.
Day 3 or Day 5 Embryo Transfer at Dominion Fertility
Embryo transfers are usually done on day 3 or day 5. Read about Dominion Fertility's IVF process and how to decide which day is the best to transfer.
PGT helps patients become parents
Dominion Fertility is now exploring performing PGT using embryo culture media. It is hoped that we can ultimately make PGT a Reproductive standard.
Your Embryos First 5 Days.
One of the important keys to success in any IVF cycle is the work that happens in the lab following the egg collection and fertilization. Contact us today.
Outstanding January 2019 IVF/PGT pregnancy rates
The month of January, 2019 was outstanding for our patients treated with IVF/PGT as 27 of 31 patients had positive pregnancy tests.
Dominion Fertility- Research Update with Igenomix
Dominion Fertility is 1 of 13 centers in 8 countries participating with Igenomix, a Reproductive research center in Spain.
Basic Infertility Evaluation Tests
Dominion Fertility is pleased to partner with our referring doctors to assist with any reproductive care. Our goal is a "Healthy Baby" one at a time!
What are the Advantages of PGT?
At Dominion Fertility we perform PGT on thousands of embryos every year and the cost for PGT is $150 per embryo plus a biopsy fee of $1,500. Call us today!
Male infertility is common and affects about 40% of infertile couples. Diagnosis of male infertility is a simple test, which only requires a semen sample
Do I Need PGS/PGT or PGD?
Terminology can be overwhelming when you are considering fertility treatment. At Dominion Fertility we want our patients to be educated and knowledgeable about their treatment options. We are going to define PGT and PGD and let you know how these tests can help you have a successful fertility outcome.
At Dominion Fertility, once our patients become successfully pregnant we continue to follow them with frequent lab draws and ultrasounds. Contact us today!
Yoga and Infertility
We know yoga can help with stress, but did you know it also helps with getting pregnant? Contact us today to learn more about how yoga can help you!
Endometriosis and Fertility
Endometriosis is a gynecologic disorder that affects about 6-10% of reproductive age women and is present in about 38% of infertile patients. Call us today!
Did you have a plan to have two or more children, but don’t understand why it is taking so long to get pregnant the second time? Contact us today!
Storage and Identity Safety for Embryos and Eggs
Here you are treated like family and so are your embryos and eggs. Your embryos and eggs will be safe with us. Contact us today!
Cryopreservation, Otherwise Known As Egg Freezing
Women who know they want to have a family, but realize it is not a short-term goal. Contact us today to learn more about our services!
What Is Endometriosis and How Is It Diagnosed?
Endometriosis is a chronic disease characterized by the growth of endometrial-like tissue beyond the normal confines of the uterine cavity. Most commonly, it is located on the ovaries, but it can also be found on any of the organs inside the pelvic–abdominal cavities. Endometriosis is usually diagnosed at the time of laparoscopic gynecologic surgery although endometriosis cysts (endometriomas) may be presumptively diagnosed on ultrasound.
Who Should Evaluate the Infertile Couple? Do I Need to See a Reproductive Endocrinologist?
A semen analysis is one of the first and most common tests done during a male fertility evaluation. Read on to learn what it tests for.
Does Surgery for Endometriosis Improve Pregnancy Rates?
Well-designed medical studies clearly show that destroying even small implants of endometriosis can improve fertility by as much as 50%. In a large Canadian study, the monthly pregnancy rate following surgical treatment of minimal endometriosis rose from 3% to 4.5%.
Do I Need Endometriosis Surgery If I Am Already Planning to Pursue IVF?
The question of endometriosis surgery prior to IVF is a somewhat controversial area of reproductive medicine. Most reproductive endocrinologists do not recommend surgery prior to IVF unless the woman has advanced endometriosis, in particular, an ovarian endometrioma.
What is ERA?
Endometrial Receptivity Array is a method of assessing when the endometrium is most receptive for the embryo to implant. Contact us today to learn more!
Can an App Help You Get Pregnant?
We welcome any questions at Dominion Fertility and would love for you to explore the “Dominion Way” for your fertility treatments. Contact us today!
How to Navigate through your IVF Medication
The most important and helpful thing for our patients is being assigned an IVF coordinator. Contact us today to learn more about our process.
Understanding the Stimulated IVF Process
In a Stimulated IVF cycle where the woman has a strong ovarian reserve, we should be able to collect between 8-15 eggs in a single cycle of Stimulated IVF.
Financing Your Fertility Treatments
Here at Dominion Fertility we understand the difficulty and emotional stress the fertility journey can have on our patients. Contact us today to learn more!
Optimizing Your Fertility
We would love to hear from you at Dominion Fertility, so give us a call or sign up for our newsletter.
When I Went In for My First Ultrasound After IVF, My RE Saw Two Gestational Sacs at 6.5 Weeks, but Only One Had a Fetal Pole With a Heartbeat. What Will Happen to the Other Pregnancy Sac?
Such events are not uncommon following IVF. The incidence of a clinical twin pregnancy after IVF is 10% to 33%, with the exact likelihood depending on the number of embryos transferred and the age of the patient.
Have sperm counts declined?
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Another one of our #DFBabies
Dominion Fertility experiences great joy when another one of our IVF babies is born. We started #DFBabies for your to see our newest baby!
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Vaccination Recommendations for Infertility Patients: receiving vaccinations before treatment for infertility begins.
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The infertility investigation should be completed in 2-3 weeks. It is very simple. Read on and watch our video which explains an infertility assessment.
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Since I see a lot of patients with PCOS in my practice, it might be helpful to share some information about what it is, and how it’s diagnosed.
Using Dr. Google
Google can help get an answer quickly, but your fertility is not something that should be solved with a search. Trust our fertility experts on these matters.
Embryo Biopsy vs. PGD (Preimplantation Genetic Diagnosis) vs. PGS (Preimplantation Genetic Screening)
We want to shed some light on the difference between Genetic Carrier Screening (blood tests), Embryo Biopsy, PGS and PGD.
Infertility Advocacy Day with Resolve
Resolve is a non-profit who works to improve the lives of people with infertility. Read how Dominion participated in Resolve's Infertility Advocacy Day.
Access to fertility care can be difficult all around the world.
Hi, this is Dr. Michael DiMattina, Medical Director of Dominion Fertility in Arlington, Virginia. Access to fertility care can be difficult,
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Learn about poor ovarian reserve and how fertility treatment from Dominion Fertility can help.
Next year is the 40th anniversary for the world’s first IVF baby…and we have been performing IVF for 33 years.
Questions You May Have During First Consult with Your Fertility Specialist
Many people have fertility questions, and ask question abut their fertility on their first consult. Let's discuss some of the common fertility questions.
How Many IVF Cycles Should I Try?
Dr. Michael DiMattina talks about the number of IVF cycles a woman should try in order to ensure a successful implantation and pregnancy.
Are Babies Born from IVF as Healthy as Other Children?
Dr. Michael DiMattina answers: are babies born from IVF as healthy as those who are born from natural conception? The answer is Yes!
How Many IVF Cycles Should a Woman Try?
A study from the U.K. found that 65% of patients were successful after 6 stimulated IVF cycles from 2003-10. However, the odds have improved greatly since.
Can I Exercise During Fertility Treatment?
Healthy babies come from healthy moms. We encourage all our patients to ask us about what would be an appropriate exercise during fertility treatment.
The Fertility Trigger Shot
During almost every type of fertility cycle that Dominion Fertility does, a HCG trigger shot is injected to increase fertility and the chances of pregnancy.
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Fertility medication and the insurance authorization process can be long and tedious. Read our tips on how to best handle this part of your fertility journey.
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Dr. DiMattina posed the question, "When should you consider undergoing IVF treatment." Read the fertility expert's response in this post.
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Dominion Fertility offers more treatment options than most fertility centers in the United States
Dominion Fertility offers more fertility options than most centers in the U.S. With experienced & dedicated doctors, learn our fertility capabilities here.
New Arlington VA office opening soon!
Dominion Fertility opened a new Arlington, VA office in November 2016. Read about what this location has to offer or stop in for a visit today!
What happened to Clomid?
Are you wondering why Clomid, the ovulation induction medication, is now trumped by Letrozole? Read why Letrozole is the new go-to for women with PCOS.
We Are a Nursing Center of Excellence!
We have been named a Nursing Center of Excellence by ASRM in 2018 for reproductive endocrinology. Schedule an appointment with our award-winning staff!
October: Breast cancer awareness month
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Dr. DiMattina quickly identifies abnormal sperm morphology in a couple trying to get pregnant for 5 years.
After 5 years of trying to get pregnant, Dr. DiMattina spotted an abnormal sperm morphology in the couple. Hear about his findings and the impact.
Meditate to improve you health and happiness.
Improving your health & happiness can provide a nice home in the womb for a baby. Learn how meditation can decrease stress, reduce pain & improve health.